Maguire obtained the concept for the challenge after speaking to Zhang and asking him what variety of latest machine would make the largest impression in biology. For Zhang, the reply was speedy: enhancing NMR. Elucidating construction is critically necessary for biologists as a result of construction determines perform, mentioned Zhang. The purpose for the undertaking was to create an NMR detector delicate sufficient to detect structural data utilizing the quantity of protein in a spot on a two-dimensional gel used for electrophoresis (about 1014 molecules). The duty was daunting. However, Zhang stated that he believes within the sentiment expressed by Francis Crick, the legendary biologist who decided the double helix construction of DNA together with James Watson: That you must ask huge questions with a purpose to get huge solutions. Zhang provides that the mission most likely by no means would have occurred with out interdisciplinary collaboration: "Biologists would by no means have considered any such machine, however a physicist would by no means have requested the query," he stated. Before beginning this venture, Maguire and Gershenfeld, with co-creator Isaac Chuang, had already used NMR to create early quantum computer systems. Their effort to enhance the computing capabilities turned out to be surprisingly related to detecting molecular constructions, an "unexpected spinoff," mentioned Gershenfeld.

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