FORMULASI GEL MINYAK YLANG-YLANG DAN UJI DAYA ANTIBAKTERI TERHADAP BAKTERI PENYEBAB JERAWAT

http://doi.org/10.22216/jit.2017.v11i3.872


tika afriani(1*)

(1) Universitas Mohammad Natsir
(*) Corresponding Author

Abstract


Minyak ylang-ylang telah diformulasi dalam bentuk sediaan gel dengan konsentrasi 3% menggunakan hidroksipropil metilselulosa sebagai bahan pembentuk gel dengan konsentrasi 2, 2,5, 3, 3,5 dan 4%. Kontrol positif adalah sediaan gel klindamisin yang beredar di pasaran. Masing-masing formula dievaluasi berupa pemerian, homogenitas, pH, uji daya menyebar, uji daya tercuci, pemeriksaan stabilitas terhadap pendinginan, dan uji mikrobiologi dengan metode difusi agar terhadap bakteri Propionibacterium acnes dan Staphylococcus epidermidis penyebab jerawat. Hasil evaluasi fisik gel menunjukkan bahwa F1 dan F2 tidak stabil selama enam minggu penyimpanan, sedangkan F3, F4, dan F5 stabil selama enam minggu penyimpanan. Hasil uji mikrobiologi gel minyak ylang-ylang menunjukkan daya hambat lemah sampai sedang terhadap bakteri penyebab jerawat. F3 merupakan formula terbaik karena stabil selama penyimpanan dan memberikan daya hambat terhadap bakteri penyebab jerawat lebih baik dibandingkan dengan F4 dan F5. Daya hambat gel minyak ylang-ylang kelima formula berbeda nyata dibandingkan dengan kontrol (p<0,05).

Keywords


Gel, minyak ylang-ylang, Propionibacterium acnes, Staphylococcus epidermidis

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References


Agnihotri, S., Wakode, S. & Agnihotri, A. 2016. Formulation And Evaluation Of Herbal Antiacne Gel Of Myrica Esculenta. Asian J Pharm Clin Res,, 9(4), pp.109–113.

Balsam, M.S & Sagarin, E. 1972. Cosmetic Science and Technology 2nd ed., New York: Willey Interscience.

Barry A.L. 1995. The antimicrobial susceptibility test principles and practices. In Philadelphia: Lea and Febiger, pp. 62–67.

Burdock GA, C.I. 2008. Review Safety assessment of Ylang-Ylang (Cananga spp.) as a food ingredient. Food Chem Toxicol, 46(2), pp.433–445.

Burrows, W. & Freeman, B.A. 1985. Textbook of Microbiology 22nd ed., New York: Suunders Company.

Chandira, R.M., Pradeep, Pasupathi, A., Bhowmik, D., Chiranjib, Jayakar, B., Tripathi, K.K., & Kumar, S. 2010. Design, Development and Formulation of Antiacne Dermatological Gel. Journal of Chemical and Pharmaceutical Research, 2(1), pp.401–414.

Depkes RI. 1995. Farmakope Indonesia 4th ed., Jakarta: Departemen Kesehatan Republik Indonesia.

Depkes RI. 1985. Farmakope Kosmetika Indonesia, Jakarta: Departemen Kesehatan Republik Indonesia.

Gennaro, A.R. 1990. Remingtons Pharmaceutical Sciences 18th ed., Penncylvania: Mack Publishing Company.

Jellinek, J.S. 1970. Formulation and Function of Cosmetics, New York: Willey Interscience.

Joshan R.S., Nagarauk R., A.P. 2010. Antibacterial properties of extracts of Indian medicinal plants: Syzygium alternifolium, Phyllanthus niruri and Rubia cordifolia. Joshan R.S., Nagarauk R., Anuradha P, 3(1), pp.123–128.

Das K, Dang R, M.U. 2009. Formulation and evaluation of a novel herbal gel of Stevia extract. Iran J Dermatol, 12(4), pp.117–122.

Lachman, L., Lieberman, H.A, & Kanig, J.L. 1973. Teori dan Praktek Farmasi Industri II, Jakarta: UI-Press.

Lay, B.W. 2001. Analisis Mikroba di Laboratorium, Jakarta: Raja Grafindo Persada.

Loh Teng H.T., Learn Han L., Wai Fong Y., Chim Kei C., Abdul Kadir H., Kok Gan C., & Bey Hing G. 2015. Traditional Uses, Phytochemistry, and Bioactivities of Cananga odorata (Ylang-Ylang). Evidence-Based Complementary and Alternative Medicine.

Luangnarumitchai S, Lamlertthon S, T.W. 2007. Antimicrobial Activity of Essential Oils Against Five Strains of Propionibacterium acnes Antimicrobial Activity of Essential Oils Against Five Strains of Propionibacterium acnes. J Pharm Sci, 34(1-4), pp.60–64.

Lynam, K. 2010. Potential Allergens in Aromatheraphy Oils by GC-MS Using an Agilent J&W DB-XLB Capillary Column.

Mayank, S. & Vikas, R. 2014. Formulation Development and Evaluation of Novel Poly-Herbal Anti-Acne Gel. International Journal of PharmTech Research, 6(1), pp.58–62.

Sanjay, Jain B.D., Padsalg A., Patel, K. & Mokale, V. 2007. Formulation development and evaluation of fluconazole gel in various polymer bases. Asian J. of pharmaceutics, 1(1).

Sawarkar, H.A., Khadabadi, S.S., Mankar, D.M., Farooqui, I.A., & Jagtap, N.S. 2010. Development and biological evaluation of herbal anti-acne gel. International Journal of PharmTech Research, 2(3), pp.2028–2031.

Sirivan, A., Rith, W., Sujimon, T., Panida, V., Paisarn, K., Prapan, S., & Nijsiri, R. 2008. The development of anti-acne products from Eucalyptus globulus and Psidium Guajava oil. J Health Res, 22(3).

Sukatta, U., Rugthaworn, P., Pitpiangchan, P., & Dilokkunanant, U. 2008. Development of Mangosteen Anti-Acne Gel. Kasetsart Journal of Natural Science, 42(5), pp.163–168.

Swarbrick, J & Boylan, J. 1992. Encyclopedia of Pharmaceutical Technology, New York: Marcel Derker, Inc.

Vijayalakshmi A, Tripura A, R. V. 2011. Development and evaluation of antiacne products from Terminalia arjuna bark. Int J ChemTech Res, 3(1), pp.320–327.

Voigt, R. 1994. Buku Pelajaran Teknologi Farmasi 5th ed., Yogyakarta: Gajah Mada University Press.

Waghmare N, Waghmare P, Wani S, Y.A. 2011. Development of Isotretinoin Gel for the Treatment of Acne Vulgaris. RJPBCS, 2(1), pp.220–230.


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