PENGARUH PEMBERIAN VITAMIN E TERHADAP KADAR PROSTAGLANDIN (PGF2α) DAN TNF α PADA PENDERITA DISMENOREA

http://doi.org/10.22216/jit.2019.v13i2.3829


rika astria rishel(1*)

(1) andalas uneversity
(*) Corresponding Author

Abstract


Pemberian vitamin E pada wanita yang mengalami dismenorea dapat secara langsung menekan kadar ROS dan dapat memperbaiki struktur memberan sel yang rusak. Penelitian ini bertujuan untuk membuktikan pengaruh pemberian vitamin E terhadap kadar Prostaglandin dan TNF-α pada penderita dismenorea. Penelitian ini merupakan  quasi eksperimental dengan desain penelitian Pre andPost Test Only Group Designyang menggunakan 22orang wanita yang mengalami dismenorea primer yang derajat 4-6. Pengambilan sampel dengan simple random sampling. Pemeriksaan kadar prostaglandin dan TNF-α dilakukan di UPTD Balai Laboratorium Kesehatan Provinsi Sumatra barat dengan metode ELISA.Hasil penelitian menunjukkan rerata kadar prostaglandin sebelum pemberian Vitamin E yaitu 205,5 ± 143,3 pg/ml, sedangkan setelah pemberian yaitu 124,8 ± 59,0 pg/ml(p<0,05). Rerata kadar TNF-α sebelum pemberian Vitamin E yaitu 207,2 ± 132,0 ng/l, sedangkan setelah pemberian yaitu 125,9 ± 35,7 ng/ll .Pada analisa data didapatkan kadar prostaglandin dan TNF-α p < 0,05. Kesimpulan penelitian ini ada pengaruh pemberian vitamin E terhadap kadar Prostaglandin dan TNF-α pada penderita dismenorea

 

Kata kunci       :Dismenorea, Prostaglandin, TNF-α


Keywords


Dismenorea, Prostaglandin, TNF-α

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References


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